Should you take a daily low dose aspirin?ĭr. government guidelines do not support aspirin use even for CV events,” Dr. “While some studies have shown reduction in cardiovascular events - e.g., heart attacks - with aspirin consumption, many studies show no benefit or, on the contrary, higher risk of death. “As is, studies have shown that too many people are taking aspirin when they are not at risk or when they should not be taking it. “A potential problem I see is people now taking aspirin without knowing the details of the study and understanding the risk of bleeding that accompanies aspirin consumption,” he said. Jagdish Khubchandani, professor of public health So, it is unclear how a study of adults more than 65 years of age will benefit the most at-risk population, even if we assume that the study findings are valid and reliable.” The age of onset of diabetes is most common in the range of 40 to 65 years. “More than a third of the people in the U.S. Jagdish Khubchandani, PhD, a professor of public health at New Mexico State University, expressed some concern about the study and told MNT the findings could give people the wrong idea. Sophia Zoungas, PhD, an endocrinologist and professor in the School of Public Health and Preventive Medicine at the Monash University in Melbourne, Australia, said in a statement that daily low dose aspirin (100 mg daily) is associated with a 15% lower risk of developing type 2 diabetes among adults ages 65 and older.ĭr. “Aspirin treatment reduced incident diabetes and slowed the increase in fasting plasma glucose over time among initially healthy older adults,” the authors said in a statement. The researchers defined incident diabetes as self-report of diabetes, commencement of glucose-lowering medication, and/or a fasting plasma glucose (FBP) level of 7.0 mmol/L or higher at annual follow-up visits.ĭuring a median follow-up of 4.7 years, 995 incident diabetes cases were recorded (aspirin: 459, placebo: 536).Ĭompared with placebo, the aspirin group had a 15% reduction in incident diabetes and a slower rate of increase in FPG (difference in annual FPG change: -0.006 mmol/L). Through computer and statistical modeling, researchers assessed the effect of aspirin on incident diabetes and FPG levels. The analysis included 16,209 participants (8,086 randomized to aspirin and 8,123 to placebo). Participants were randomized 1:1 to 100 mg daily aspirin or a placebo. They excluded subjects with diabetes at the beginning of the study. The researchers looked at community-dwelling people 65 or over who were free of cardiovascular disease, independence-limiting physical disability, and dementia. The study investigated the randomized treatment effect of low dose aspirin on incident diabetes and fasting plasma glucose (FPG) levels among older adults. Parlow.How does low dose aspirin impact type 2 diabetes risk? Our research team works side-by-side with patients, surgeons, nurses and with the input of the other members of the Department of Anesthesiology and Perioperative Medicine,” says Dr. “KGH was able to be a vital contributor to this important study due to the dedication of our excellent research nurses Debbie Dumerton-Shore, Jessica McCourt and Beth Orr, and my co-investigator René Allard. Devereaux (McMaster University’s Population Health Research Institute). The POISE-2 study was designed and led by Principal Investigator P. More than 400 patients were enlisted from KGH, making it the fourth-largest recruiting site in the world, after Hamilton Health Sciences Centre and The Cleveland Clinic. With over 10,000 patients from 23 countries and 135 centres, the study is the largest clinical trial to evaluate major cardiovascular complications in non-cardiac surgeries. “This is important news for the medical community and for patients with risk factors for heart disease who are set to undergo non-cardiac surgery.” “In fact, Aspirin was shown to increase the risk of serious bleeding after surgery, in some cases,” says Joel Parlow, Head of Anesthesiology and Perioperative Medicine at both Queen’s and KGH and the hospital’s POISE-2 Site Principal Investigator. Researchers Debbie Dumerton-Shore, Joel Parlow, Jessica McCourt and Rene Allard are part of a ground breaking study investigating the use of Aspirin to protect the heart after surgery.
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